Acute generalized exanthematous pustulosis
I- Acute generalized exanthematous pustulosis (AGEP) ukusabela kwesikhumba okungajwayelekile okuthi kuma-90% ezimo kuhlobene nokuphathwa kwemithi. I- acute generalized exanthematous pustulosis ibonakala ngokuqhuma kwesikhumba okungazelelwe okuvela ngokwesilinganiso ezinsukwini ezinhlanu ngemva kokuqaliswa komuthi. Lokhu kuqhuma ama-pustules, okungukuthi ukuqhuma okuncane okumhlophe okubomvu noma okubomvu kwesikhumba okuqukethe okunamafu noma oku-purulent (ubovu). Izilonda zesikhumba zivame ukuxazululeka phakathi kwezinsuku ezingu-1-3 zokuyeka imithi ehlukumezayo.
☆ Emiphumeleni ka-2022 ye-Stiftung Warentest evela eJalimane, ukwaneliseka kwabathengi nge-ModelDerm bekungaphansi kancane kunokuxhumana okukhokhelwayo kwe-telemedicine.
Izilonda ezisabalele nge-erythema nama-pustules zivela ngokuzumayo.
References
I- Acute generalized exanthematous pustulosis (AGEP) ukusabela kwesikhumba okumakwa ngamaqhubu amancane, agcwele ubomvu esisekelweni sesikhumba esibomvu. Ngokuvamile kwenzeka lapho othile ethatha imithi ethile, njengama-antibiotics, futhi asakazeka ngokushesha kuwo wonke umzimba. Ngemuva kokuyeka imishanguzo eqalayo, izimpawu ngokuvamile ziyaphela phakathi namasonto amabili, ngokuvamile kushiya ukuchitheka okuthile kwesikhumba. Nakuba ngokuvamile kungenabungozi futhi kukhawulelwe esikhumbeni, izimo ezinzima zingahlukaniswa ngokuhambisana nokunye ukusabela okubucayi kwesikhumba okufana nokuthi Stevens-Johnson syndrome noma toxic epidermal necrolysis. Ukwelashwa ngokuyinhloko kuwukunakekela okusekelayo, futhi ukubikezelwa kokuxazulula lesi sifo ngokuvamile kuhle kakhulu.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Ikhehla elineminyaka engu-76 ubudala lafika egunjini labezimo eziphuthumayo ngenxa yokuthi isikhumba salo sase sishintshile ezinsukwini ezimbili ezedlule. Odokotela bathola amabala abomvu futhi baphakamisa izindawo esiqwini sakhe nasezingalweni nasemilenzeni. Ngokuhamba kwesikhathi, la mabala ahlangana ndawonye, futhi waba namaqhubu anjengezinduna ezindaweni ezibomvu. Ukuhlola kubonise inani eliphezulu lamaseli amhlophe egazi anohlobo oluningi olubizwa ngokuthi ama-neutrophils, kanye namazinga anyusiwe angu- C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
